RFamide-Related Peptide Gene Is a Melatonin-Driven Photoperiodic Gene

Comparison between Brain Natriuretic Peptide and Calcitonin Gene Related Peptide in Children with Dilated Cardiomyopathy

Background: Dilated cardiomyopathy (DCM) is revealed with the left ventricular dilatation and systolic dysfunction. This study was performed to determine the level of Calcitonin Gene Related Peptide (CGRP) and Brain Natriuretic Peptide (BNP) in children with dilated cardiomyopathy and controls and comparison of these two biomarkers in patients. Materials and Methods: This case-control study was...

Calcitonin gene related peptide.

Renal mesangium is a target for calcitonin gene-related peptide.

Rat calcitonin gene-related peptide (CGRP alpha; EC50, 1 nM) was shown to stimulate cAMP formation in cultured rat renal mesangial cells. CGRP concentration dependently (EC50, 1 nM) also inhibited contraction of mesangial cells by angiotensin II (10 nM). Angiotensin II (10 nM) caused a transient increase of the intracellular calcium concentration from 140 nM to 480 nM in the mesangial cells, bu...

Calcitonin gene-related peptide is a stimulator of renin secretion.

Calcitonin gene-related peptide (CGRP) was found to stimulate renin secretion in vivo in normal human volunteers. Moreover, CGRP stimulated the release of renin in vitro from isolated rat renal juxtaglomerular cells (half-maximal effective concentration [EC50] 100 nM) concomitant with stimulation of cAMP production (EC50 60 nM). Immunoreactive CGRP was recognized in rat renal cortical nerve fib...

بررسی تأثیر نورپپتیدهایcalcitonin gene related peptide (cgrp) و substance p (sp) بر تکثیر، بروز مولکولهای چسبان سلولی و قدرت کلنی زایی سلولهای cd34+ خون بند ناف

تعامل واسطه های بیولوژیک از جمله سایتوکاینها و نوروپپتیدها در بافتهای خونساز بر فعالیت سلولهای ایمونوهماتوپوئتیک موثر است. عمدهٌ مطالعات در این زمینه بر نقش سایتوکاینها متمرکز بوده و شناخت نقش تنظیمی نوروپپتیدها کمتر مورد توجه قرار گرفته است. لذا در این تحقیق اثر دو نوروپپتید spو cgrp، بر سلولهای بنیادی خون بندناف بررسی شد. پس از نمونه گیری از خون بندناف و جداسازی سلولهای بنیادیcd34+ به وسیله ...